primer over paint over paint over paint

Well it's been awhile since I used a paint brush or roller; since I had nothing better to do I thought I would paint.  Just kidding, I'm actually kind of tired of painting.  Due to the excessive smoking that took place in the master bedroom by the previous owners I noticed an issue.  There was a wallpaper border in that room.  After removing it and sanding and priming that area there was a discrepancy in the color of the wall.  The white primer on the border area was substantially whiter than the wall area, even though I had already painted the wall white. hmmmm.  Well after painting it again it still wasn't white. Then I realized the yellowish hue probably was from the smoke, and it kept leeching through the latex paint.  Even latex Kilz wouldn't kill it.  I had to resort to the same oil base primer that was used on the border area.  Not very eco-friendly but there really was no choice in the matter.  The entire room needed primed, again, to cover up the yellowish tint. Oil based primer does not smell very good, as you may know. After some toxic fume inhalation burning my last few brain cells, its done now!  Time to get the latex paint out again and go over the primer.  I think I've lost a couple inches in this room from all the paint. :-)   Good times, good times!